Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium-valproat
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IMPROVED CHROMATOGRAPHIC METHOD FOR DETERMINATION OF SODIUM DICLOFENAC IN INJECTABLE SOLUTION AND PREDICTION OF CHEMICAL STABILITY
Two modified methods for assaying sodium diclofenac were developed by GC and HPLC. Diclofenac was converted into methyl ester derivative by methyl iodide in acetone. The ester was extract and subjected to GLC with flame ionization detector. %5 SE-30/chrom W-HP (80-100 mesh) was used as a column in GC. For reversed phase HPLC, the mobile phase was methanol and water (55-45). The separation was p...
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ژورنال
عنوان ژورنال: Arhiv za farmaciju
سال: 2014
ISSN: 0004-1963
DOI: 10.5937/arhfarm1402128k